Office: 3SCR6.4610-7, 1881 East Road, Houston Texas 77054
Program: PhD Track: Medicinal Chemistry Advisor: Xiang-Qun (Sean) Xie, PhD, EMBA
To become a radiotherapy doctor, I graduated from School of Medicine in Soochow University with MD degree. My professional career started from Radiotherapy Center in Changhai Hospital in China. By working as a resident doctor in Changhai hospital for 1 year, I learnt diagnosing tumor and making therapy plan for individual tumor patient. 3DCRT (3-dimensional conformal radiation therapy) and IMRT (Intensity-modulated radiation therapy) are major techniques we used. Besides tumor treatment, we also performed total body irradiation on leukemia patients before transplantation. Another my expertise is performing radiotherapy on Graves’ Disease, which requires accurate localization of radiotherapy targeting. With certain experience on operating irradiator, especially for leukemia patients who needed transplantation, Dr. Tao Cheng, who was professor in Department of Radiation Oncology in University of Pittsburgh, invited me as Visiting Scholar in his laboratory. I was involved in a project named “negative effects of irradiated hosts on transplanted Hematopoietic Stem Cells (HSCs)” aiming to quantify the negative effects, the mechanisms, and improvement of HSC engraftment by manipulating irradiated host microenvironment. During the following 3 years’ laboratory work, I took in charge of mice breeding, Hematopoietic Stem Cell transplantation on mice, operating irradiator to irradiate mice. In 2012, as a co-author, we published a paper in Blood based on our finding related to the negative effect of residual radiation on transplanted host, the correlation between Reactive Oxygen Species (ROS) and stem cell growth factor receptors (c-kit) down-regulation. To obtain formal PhD training in Pharmaceutical Sciences, I have been admitted to University of Pittsburgh School of Pharmacy as PhD student since 2013. In the first two years, besides course work for PhD training, I devoted most of my time for research to a project “small molecules virtual screening for Hematopoietic Stem Cell ex vivo expansion” by setting up knowledgebase of signaling pathways related to stem cell self-renew and performing radioactive isotope marked bioassay for small molecules binding validation. After finishing course work, I joined in Dr. Johnny Huard’s lab in UTHealth to achieve my major project for my PhD dissertation on muscle-derived stem/progenitor cell.