Directory Profile

Raman Venkataramanan, PhD

Office: 7354 Salk Hall, 3501 Terrace St, 15261

Phone: 412-648-8547

Pager: 412-565-8589



Raman Venkataramanan is Professor of Pharmaceutical Sciences at the University of Pittsburgh School of Pharmacy. He holds an appointment as Professor of Pathology in the University of Pittsburgh School of Medicine. He is a member of the Thomas E. Starzl Transplantation Institute, Clinical Translational Science Institute, University of Pittsburgh Medical Center, Magee Womens Research Institute, McGowern Institute for Regenerative Medicine. He is the Director of the Clinical Pharmacokinetics Laboratory in the School of Pharmacy and Director of Therapeutic Drug Monitoring and Co-director of Toxicology in the department of Pathology at the University of Pittsburgh.

He received his B.Pharm degree from University of Madras in Madras, India; M.Pharm degree from BITS, Pilani, India and Ph.D. from University of British Columbia, Vancouver, Canada. After a postdoctoral fellowship in the University of Washington, he joined at the University of Pittsburgh in 1980. He has been appointed as a Food and Drug Administration Special Government Employee by the CDER.

He has been reviewer for NCCAM, NIH, MRC and several journals. He has presented one hundred and seventy lectures at national and international meetings. He has published nearly 400 research articles. Dr. Venkataramanan has been a visiting scientists for the Alberta Heritage Foundation, MRC Canada and KJ Hospital India. Dr. Venkataramanan is a Fellow of the American College of Clinical Pharmacology and the American Association of Pharmaceutical Scientists. He received the Orator award from the First Scientific session of the Sri Lanka Association of Nephrology and Transplantation (SLANT) in 1995. In 1998, he received the Ranbaxy Research Award in Pharmaceutical Sciences for excellence in research.

He is the recipient of BMS Mentorship in Clinical Pharmacology offered by ACCP (2009); Provost’s Award for Excellence in Graduate Education offered by the University of Pittsburgh (2009); Innovations in Teaching award offered by Rho Chi Society at the University of Pittsburgh (2009) and Scholarly contributions award offered by Rho Chi Society at the University of Pittsburgh (2007); Tyler award for stimulation of research (APhA 2011). He has been an active member in IATDMCT, AAPS, ATS, ACCP, AACC and AACP.

Drug disposition in transplant patients; regulation of drug
metabolism; drug metabolism and transport during pregnancy.

2018-2020 (May)

1: Hauspurg A, Lemon L, Venkataramanan R, Caritis SN. Reply. Am J Obstet
Gynecol. 2019 Jun;220(6):608-609. doi: 10.1016/j.ajog.2019.02.031. Epub 2019 Feb
18. PMID: 30790567.

2: Lemon LS, Caritis SN, Venkataramanan R, Platt RW, Bodnar LM. Methadone Versus
Buprenorphine for Opioid Use Dependence and Risk of Neonatal Abstinence
Syndrome. Epidemiology. 2018 Mar;29(2):261-268. doi:
10.1097/EDE.0000000000000780. PMID: 29112519; PMCID: PMC5792296.

3: Ryu RJ, Easterling TR, Caritis SN, Venkataramanan R, Umans JG, Ahmed MS,
Clark S, Kantrowitz-Gordon I, Hays K, Bennett B, Honaker MT, Thummel KE, Shen
DD, Hebert MF. Prednisone Pharmacokinetics During Pregnancy and Lactation. J
Clin Pharmacol. 2018 Sep;58(9):1223-1232. doi: 10.1002/jcph.1122. Epub 2018 May
7. PMID: 29733485; PMCID: PMC6310475.

4: Ensor CR, Goehring KC, Iasella CJ, Moore CA, Lendermon EA, McDyer JF, Morrell
MR, Sciortino CM, Venkataramanan R, Wiland AM. Belatacept for maintenance
immunosuppression in cardiothoracic transplantation: The potential frontier.
Clin Transplant. 2018 Oct;32(10):e13363. doi: 10.1111/ctr.13363. Epub 2018 Sep
10. PMID: 30058177.

5: Zhang H, Kalluri HV, Bastian JR, Chen H, Alshabi A, Caritis SN,
Venkataramanan R. Gestational changes in buprenorphine exposure: A
physiologically-based pharmacokinetic analysis. Br J Clin Pharmacol. 2018
Sep;84(9):2075-2087. doi: 10.1111/bcp.13642. Epub 2018 Jun 21. PMID: 29873094;
PMCID: PMC6089832.

6: Wu X, Clancy CJ, Rivosecchi RM, Zhao W, Shields RK, Marini RV, Venkataramanan
R, Nguyen MH. Pharmacokinetics of Intravenous Isavuconazole in Solid-Organ
Transplant Recipients. Antimicrob Agents Chemother. 2018 Nov
26;62(12):e01643-18. doi: 10.1128/AAC.01643-18. PMID: 30275091; PMCID:

7: Lemon LS, Naimi A, Caritis SN, Platt RW, Venkataramanan R, Bodnar LM. The
Role of Preterm Birth in the Association Between Opioid Maintenance Therapy and
Neonatal Abstinence Syndrome. Paediatr Perinat Epidemiol. 2018
Mar;32(2):213-222. doi: 10.1111/ppe.12443. Epub 2018 Jan 26. PMID: 29372750;
PMCID: PMC5902412.

8: Elens L, Langman LJ, Hesselink DA, Bergan S, Moes DJAR, Molinaro M,
Venkataramanan R, Lemaitre F. Pharmacologic Treatment of Transplant Recipients
Infected With SARS-CoV-2: Considerations Regarding Therapeutic Drug Monitoring
and Drug-Drug Interactions. Ther Drug Monit. 2020 Jun;42(3):360-368. doi:
10.1097/FTD.0000000000000761. PMID: 32304488; PMCID: PMC7188032.

9: Xu J, Sun J, Ho PY, Luo Z, Ma W, Zhao W, Rathod SB, Fernandez CA,
Venkataramanan R, Xie W, Yu AM, Li S. Creatine based polymer for codelivery of
bioengineered MicroRNA and chemodrugs against breast cancer lung metastasis.
Biomaterials. 2019 Jul;210:25-40. doi: 10.1016/j.biomaterials.2019.04.025. Epub
2019 Apr 26. PMID: 31054369; PMCID: PMC6538300.

10: Caritis SN, Hauspurg A, Venkataramanan R, Lemon L. Defining the clinical
response to 17-alpha hydroxyprogesterone caproate. Am J Obstet Gynecol. 2018
Dec;219(6):623-625. doi: 10.1016/j.ajog.2018.08.040. Epub 2018 Aug 29. PMID:

11: Thanukrishnan H, Corcoran TE, Iasella CJ, Moore CA, Nero JA, Morrell MR,
McDyer JF, Hussain S, Nguyen MH, Venkataramanan R, Ensor CR. Aerosolization of
Second-generation Triazoles: In Vitro Evaluation and Application in Therapy of
Invasive Airway Aspergillosis. Transplantation. 2019 Dec;103(12):2608-2613. doi:
10.1097/TP.0000000000002697. PMID: 31343565.

12: Liu L, Wheeler SE, Venkataramanan R, Rymer JA, Pizon AF, Lynch MJ, Tamama K.
Newly Emerging Drugs of Abuse and Their Detection Methods: An ACLPS Critical
Review. Am J Clin Pathol. 2018 Jan 29;149(2):105-116. doi: 10.1093/ajcp/aqx138.
PMID: 29385414.

13: Liao MZ, Flood Nichols SK, Ahmed M, Clark S, Hankins GD, Caritis S,
Venkataramanan R, Haas D, Quinney SK, Haneline LS, Tita AT, Manuck T, Wang J,
Thummel KE, Brown LM, Ren Z, Easterling TR, Hebert MF. Effects of Pregnancy on
the Pharmacokinetics of Metformin. Drug Metab Dispos. 2020 Apr;48(4):264-271.
doi: 10.1124/dmd.119.088435. Epub 2020 Jan 24. PMID: 31980499; PMCID:

14: Kalaiarasi R, Vijayakumar C, Archana R, Venkataramanan R, Chidambaram R,
Shrinuvasan S, Prabhu R. Role of Thermography in the Diagnosis of Chronic
Sinusitis. Cureus. 2018 Mar 10;10(3):e2298. doi: 10.7759/cureus.2298. PMID:
29755895; PMCID: PMC5945270.

15: Kalaiarasi R, Kiran AS, Vijayakumar C, Venkataramanan R, Manusrut M, Prabhu
R. Anatomical Features of Intratemporal Course of Facial Nerve and its
Variations. Cureus. 2018 Aug 2;10(8):e3085. doi: 10.7759/cureus.3085. PMID:
30324041; PMCID: PMC6171777.

16: Caritis SN, Hankins G, Hebert M, Haas DM, Ahmed M, Simhan H, Haneline LA,
Harris J, Chang J, Famy AS, Yorio P, Ren Z, D'Alton ME, Venkataramanan R. Impact
of Pregnancy History and 17-Hydroxyprogesterone Caproate on Cervical Cytokines
and Matrix Metalloproteinases. Am J Perinatol. 2018 Apr;35(5):470-480. doi:
10.1055/s-0037-1608631. Epub 2017 Nov 15. PMID: 29141262; PMCID: PMC5876094.

17: Basagoudanavar SH, Hosamani M, Tamil Selvan RP, Sreenivasa BP, Sanyal A,
Venkataramanan R. Host serum microRNA profiling during the early stage of foot-
and-mouth disease virus infection. Arch Virol. 2018 Aug;163(8):2055-2063. doi:
10.1007/s00705-018-3824-8. Epub 2018 Apr 3. PMID: 29616415.

18: Clark AM, Kumar MP, Wheeler SE, Young CL, Venkataramanan R, Stolz DB,
Griffith LG, Lauffenburger DA, Wells A. A Model of Dormant-Emergent Metastatic
Breast Cancer Progression Enabling Exploration of Biomarker Signatures. Mol Cell
Proteomics. 2018 Apr;17(4):619-630. doi: 10.1074/mcp.RA117.000370. Epub 2018 Jan
20. PMID: 29353230; PMCID: PMC5880110.

19: Xu J, Zhao W, Sun J, Huang Y, Wang P, Venkataramanan R, Yang D, Ma X, Rana
A, Li S. Novel glucosylceramide synthase inhibitor based prodrug copolymer
micelles for delivery of anticancer agents. J Control Release. 2018 Oct
28;288:212-226. doi: 10.1016/j.jconrel.2018.09.011. Epub 2018 Sep 14. PMID:
30223045; PMCID: PMC6177216.

20: Shah M, Xu M, Shah P, Wang X, Clark SM, Costantine M, West HA, Nanovskaya
TN, Ahmed MS, Abdel-Rahman SZ, Venkataramanan R, Caritis SN, Hankins GDV,
Rytting E. Effect of CYP2C9 Polymorphisms on the Pharmacokinetics of
Indomethacin During Pregnancy. Eur J Drug Metab Pharmacokinet. 2019
Feb;44(1):83-89. doi: 10.1007/s13318-018-0505-7. PMID: 30159654; PMCID:

21: Sin SH, Eason AB, Bigi R, Kim Y, Kang S, Tan K, Seltzer TA, Venkataramanan
R, An H, Dittmer DP. Kaposi's Sarcoma-Associated Herpesvirus Latency Locus
Renders B Cells Hyperresponsive to Secondary Infections. J Virol. 2018 Sep
12;92(19):e01138-18. doi: 10.1128/JVI.01138-18. PMID: 30021906; PMCID:

22: Ensor CR, Iasella CJ, Harrigan KM, Morrell MR, Moore CA, Shigemura N, Zeevi
A, McDyer JF, Venkataramanan R. Increasing tacrolimus time-in-therapeutic range
is associated with superior one-year outcomes in lung transplant recipients. Am
J Transplant. 2018 Jun;18(6):1527-1533. doi: 10.1111/ajt.14723. Epub 2018 Apr 6.
PMID: 29513387.

23: Hauspurg A, Lemon LS, Serra AE, Sharma S, Venkataramanan R, Caritis SN.
Impact of Obesity on the Rate of Recurrent Spontaneous Preterm Birth in Women
Treated with 17-alpha Hydroxyprogesterone Caproate. Am J Perinatol. 2018
Jul;35(9):809-814. doi: 10.1055/s-0037-1617453. Epub 2018 Jan 2. PMID: 29294501.

24: Feturi FG, Weinstock M, Zhao W, Zhang W, Schnider JT, Erbas VE, Oksuz S,
Plock JA, Rohan L, Spiess AM, Ferreira LM, Solari MG, Venkataramanan R, Gorantla
VS. Mycophenolic Acid for Topical Immunosuppression in Vascularized Composite
Allotransplantation: Optimizing Formulation and Preliminary Evaluation of
Bioavailability and Pharmacokinetics. Front Surg. 2018 May 9;5:20. doi:
10.3389/fsurg.2018.00020. PMID: 29868602; PMCID: PMC5954844.

25: Lu J, Zhao W, Huang Y, Liu H, Marquez R, Gibbs RB, Li J, Venkataramanan R,
Xu L, Li S, Li S. Correction to "Targeted Delivery of Doxorubicin by Folic Acid-
Decorated Dual Functional Nanocarrier". Mol Pharm. 2019 Sep 3;16(9):4087. doi:
10.1021/acs.molpharmaceut.9b00818. Epub 2019 Aug 9. Erratum for: Mol Pharm. 2014
Nov 3;11(11):4164-78. PMID: 31397164.

26: Lemon LS, Bodnar LM, Garrard W, Venkataramanan R, Platt RW, Marroquin OC,
Caritis SN. Ondansetron use in the first trimester of pregnancy and the risk of
neonatal ventricular septal defect. Int J Epidemiol. 2020 Apr 1;49(2):648-656.
doi: 10.1093/ije/dyz255. PMID: 31860078; PMCID: PMC7266534.

27: Shuster DL, Shireman LM, Ma X, Shen DD, Flood Nichols SK, Ahmed MS, Clark S,
Caritis S, Venkataramanan R, Haas DM, Quinney SK, Haneline LS, Tita AT, Manuck
TA, Thummel KE, Brown LM, Ren Z, Brown Z, Easterling TR, Hebert MF.
Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination
Therapy in the Treatment of Gestational Diabetes Mellitus. Clin Pharmacol Ther.
2020 Jun;107(6):1362-1372. doi: 10.1002/cpt.1749. Epub 2020 Jan 25. PMID:

28: Wang P, Shehu AI, Lu J, Joshi RH, Venkataramanan R, Sugamori KS, Grant DM,
Zhong XB, Ma X. Deficiency of N-acetyltransferase increases the interactions of
isoniazid with endobiotics in mouse liver. Biochem Pharmacol. 2017 Dec
1;145:218-225. doi: 10.1016/j.bcp.2017.09.001. Epub 2017 Sep 6. PMID: 28888949;
PMCID: PMC5681379.

29: Wu X, Zhang H, Miah MK, Caritis SN, Venkataramanan R. Physiologically Based
Pharmacokinetic Approach Can Successfully Predict Pharmacokinetics of Citalopram
in Different Patient Populations. J Clin Pharmacol. 2020 Apr;60(4):477-488. doi:
10.1002/jcph.1541. Epub 2019 Nov 21. PMID: 31750550.

30: Wu X, Venkataramanan R, Rivosecchi RM, Tang C, Marini RV, Shields RK, Clancy
CJ, Nguyen MH. Population Pharmacokinetics of Intravenous Isavuconazole in
Solid-Organ Transplant Recipients. Antimicrob Agents Chemother. 2020 Jan
27;64(2):e01728-19. doi: 10.1128/AAC.01728-19. PMID: 31767725; PMCID:

31: Shuster DL, Shireman LM, Ma X, Shen DD, Flood Nichols SK, Ahmed MS, Clark S,
Caritis S, Venkataramanan R, Haas DM, Quinney SK, Haneline LS, Tita AT, Manuck
TA, Thummel KE, Morris Brown L, Ren Z, Brown Z, Easterling TR, Hebert MF.
Pharmacodynamics of Metformin in Pregnant Women With Gestational Diabetes
Mellitus and Nonpregnant Women With Type 2 Diabetes Mellitus. J Clin Pharmacol.
2020 Apr;60(4):540-549. doi: 10.1002/jcph.1549. Epub 2019 Nov 19. PMID:
31742716; PMCID: PMC7064374.

32: Zhang H, Bastian JR, Zhao W, Chen H, Shaik IH, Chaphekar N, Caritis SN,
Venkataramanan R. Pregnancy Alters CYP- and UGT-Mediated Metabolism of
Buprenorphine. Ther Drug Monit. 2020 Apr;42(2):264-270. doi:
10.1097/FTD.0000000000000724. PMID: 31929398.

33: Caritis SN, Venkataramanan R. Naltrexone use in pregnancy: a time for
change. Am J Obstet Gynecol. 2020 Jan;222(1):1-2. doi:
10.1016/j.ajog.2019.08.041. PMID: 31883574.

34: Lemaitre F, Vethe NT, D'Avolio A, Tron C, Robertsen I, De Winter B, Denicolo
A, Koch BCP, Venkataramanan R, Van Gelder T, Brunet M, Bergan S, Hesselink DA,
Wallemacq P. Measuring Intracellular Concentrations of Calcineurin Inhibitors:
Expert Consensus from the International Association of Therapeutic Drug
Monitoring and Clinical Toxicology (IATDMCT) Expert Panel. Ther Drug Monit. 2020
Jun 8. doi: 10.1097/FTD.0000000000000780. Epub ahead of print. PMID: 32520841.

Pregnancy and Drug Metabolizing Enzymes and Transporters
Raman Venkataramanan, PhD

T32 for Maternal fetal pharmacology

Metabolism of 17-hydroxy progesterone caproate
Raman Venkataramanan, PhD

Granisetron PK in pregnancy
Raman Venkataramanan, Ph.D.

Tamiflu Pk in Pregnancy
Raman Venkataramanan, Ph.D.

Remodlin for I/R injury of liver
Raman venkataramanan, Ph.D.

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