Office: 718 Salk Hall

Phone: 412-648-8547

Fax: 412-648-7671

Pager: 412-565-8589

Email: rv@pitt.edu

Raman Venkataramanan is Professor of Pharmaceutical Sciences at the University of Pittsburgh School of Pharmacy. He holds an appointment as Professor of Pathology in the University of Pittsburgh School of Medicine. He is a member of the Thomas E. Starzl Transplantation Institute, Center for Clinical Pharmacology, CTSI, UPCI, MWRI and MIRM. He is the Director of the Clinical Pharmacokinetics Laboratory in the School of Pharmacy and Director of TDM in the department of Pathology at the University of Pittsburgh.

He received his B.Pharm degree from University of Madras in Madras, India; M.Pharm degree from BITS, Pilani, India and Ph.D. from University of British Columbia, Vancouver, Canada. After a postdoctoral fellowship in the University of Washington, he joined at the University of Pittsburgh in 1980. He has been appointed as a Food and Drug Administration Special Government Employee by the CDER.

He has been reviewer for NCCAM, NIH, MRC and several journals. He has presented one hundred and thirty lectures at national and international meetings. He has published more than 270 research articles. Dr. Venkataramanan has been a visiting scientists for the Alberta Heritage Foundation, MRC Canada and KJ Hospital India. Dr. Venkataramanan is a Fellow of the American College of Clinical Pharmacology and the American Association of Pharmaceutical Scientists. He received the Orator award from the First Scientific session of the Sri Lanka Association of Nephrology and Transplantation (SLANT) in 1995. In 1998, he received the Ranbaxy Research Award in Pharmaceutical Sciences for excellence in research.

He is the recipient of BMS Mentorship in Clinical Pharmacology offered by ACCP (2009); Provost’s Award for Excellence in Graduate Education offered by the University of Pittsburgh (2009); Innovations in Teaching award offered by Rho Chi Society at the University of Pittsburgh (2009) and Scholarly contributions award offered by Rho Chi Society at the University of Pittsburgh (2007); Tyler award for stimulation of research (APhA 2011). He has been an active member in IATDMCT, AAPS, ACCP, AACC and AACP.


Drug disposition in transplant patients; regulation of drug
metabolism; drug metabolism and transport during pregnancy.

1: Gramignoli R, Tahan V, Dorko K, Skvorak KJ, Hansel MC, Zhao W, Venkataramanan
R, Ellis EC, Jorns C, Ericzon BG, Rosenborg S, Kuiper R, Soltys KA, Mazariegos
GV, Fox IJ, Wilson EM, Grompe M, Strom SC. New potential cell source for
hepatocyte transplantation: Discarded livers from metabolic disease liver
transplants. Stem Cell Res. 2013 Jul;11(1):563-73. doi:
10.1016/j.scr.2013.03.002. Epub 2013 Mar 27. PubMed PMID: 23644508.

2: Caritis SN, Zhao Y, Venkataramanan R, Bettinger J. Reply. Am J Obstet Gynecol.
2013 Apr 30. doi:pii: S0002-9378(13)00472-9. 10.1016/j.ajog.2013.04.038. [Epub
ahead of print] PubMed PMID: 23643571.

3: Schnider JT, Weinstock M, Plock JA, Solari MG, Venkataramanan R, Zheng XX,
Gorantla VS. Site-specific immunosuppression in vascularized composite
allotransplantation: prospects and potential. Clin Dev Immunol. 2013;2013:495212.
doi: 10.1155/2013/495212. Epub 2013 Feb 13. PubMed PMID: 23476677; PubMed CentralPMCID: PMC3586464.

4: Caritis SN, Zhao Y, Bettinger J, Venkataramanan R. Qualitative and
quantitative measures of various compounded formulations of 17-alpha
hydroxyprogesterone caproate. Am J Obstet Gynecol. 2013 Jun;208(6):470.e1-5. doi:
10.1016/j.ajog.2013.02.028. Epub 2013 Feb 20. PubMed PMID: 23453884; PubMed
Central PMCID: PMC3672260.

5: Zhang X, Lu J, Huang Y, Zhao W, Chen Y, Li J, Gao X, Venkataramanan R, Sun M,
Stolz DB, Zhang L, Li S. PEG-farnesylthiosalicylate conjugate as a nanomicellar
carrier for delivery of paclitaxel. Bioconjug Chem. 2013 Mar 20;24(3):464-72.
doi: 10.1021/bc300608h. Epub 2013 Mar 1. PubMed PMID: 23425093; PubMed Central
PMCID: PMC3623935.

6: Roy D, Sin SH, Lucas A, Venkataramanan R, Wang L, Eason A, Chavakula V, Hilton
IB, Tamburro KM, Damania B, Dittmer DP. mTOR inhibitors block Kaposi sarcoma
growth by inhibiting essential autocrine growth factors and tumor angiogenesis.
Cancer Res. 2013 Apr 1;73(7):2235-46. doi: 10.1158/0008-5472.CAN-12-1851. Epub
2013 Feb 4. PubMed PMID: 23382046; PubMed Central PMCID: PMC3618543.

7: Goyal RK, Han K, Wall DA, Pulsipher MA, Bunin N, Grupp SA, Mada SR,
Venkataramanan R. Sirolimus pharmacokinetics in early postmyeloablative pediatric
blood and marrow transplantation. Biol Blood Marrow Transplant. 2013
Apr;19(4):569-75. doi: 10.1016/j.bbmt.2012.12.015. Epub 2012 Dec 21. PubMed PMID:
23266742.

8: Pillai VC, Strom SC, Caritis SN, Venkataramanan R. A sensitive and specific
CYP cocktail assay for the simultaneous assessment of human cytochrome P450
activities in primary cultures of human hepatocytes using LC-MS/MS. J Pharm
Biomed Anal. 2013 Feb 23;74:126-32. doi: 10.1016/j.jpba.2012.10.016. Epub 2012
Oct 22. PubMed PMID: 23245243; PubMed Central PMCID: PMC3654816.

9: Lu J, Huang Y, Zhao W, Marquez RT, Meng X, Li J, Gao X, Venkataramanan R, Wang
Z, Li S. PEG-derivatized embelin as a nanomicellar carrier for delivery of
paclitaxel to breast and prostate cancers. Biomaterials. 2013 Feb;34(5):1591-600.
doi: 10.1016/j.biomaterials.2012.10.073. Epub 2012 Nov 23. PubMed PMID: 23182923;
PubMed Central PMCID: PMC3529003.

10: Sharma S, Ellis EC, Gramignoli R, Dorko K, Tahan V, Hansel M, Mattison DR,
Caritis SN, Hines RN, Venkataramanan R, Strom SC. Hepatobiliary disposition of
17-OHPC and taurocholate in fetal human hepatocytes: a comparison with adult
human hepatocytes. Drug Metab Dispos. 2013 Feb;41(2):296-304. doi:

10.1124/dmd.112.044891. Epub 2012 Nov 5. PubMed PMID: 23129211; PubMed Central
PMCID: PMC3558857.
11: Cuppett CD, Zhao Y, Caritis S, Zhang S, Zhao W, Venkataramanan R. Effect of
endogenous steroid hormones on 17-alpha-hydroxyprogesterone caproate metabolism.
Am J Obstet Gynecol. 2013 Jan;208(1):86.e1-6. doi: 10.1016/j.ajog.2012.09.021.
Epub 2012 Sep 28. PubMed PMID: 23063018.

12: Momper JD, Zhao Y, Shapiro R, Schonder KS, Gao Y, Randhawa PS, Venkataramanan
R. Pharmacokinetics of low-dose cidofovir in kidney transplant recipients with BK
virus infection. Transpl Infect Dis. 2013 Feb;15(1):34-41. doi:
10.1111/tid.12014. Epub 2012 Oct 2. PubMed PMID: 23025519; PubMed Central PMCID:
PMC3654813.

13: Caritis SN, Sharma S, Venkataramanan R, Hankins GD, Miodovnik M, Hebert MF,
Umans JG, Benedetti T, Mattison D, Zajicek A, Fischer D, Jackson A; Eunice
Kennedy Shriver National Institute of Child Health and Human Development
Obstetrical-Fetal Pharmacology Research Units Network. Pharmacology and placental
transport of 17-hydroxyprogesterone caproate in singleton gestation. Am J Obstet
Gynecol. 2012 Nov;207(5):398.e1-8. doi: 10.1016/j.ajog.2012.08.015. Epub 2012 Aug
16. PubMed PMID: 22967833; PubMed Central PMCID: PMC3586341.

14: Caritis SN, Simhan HN, Zhao Y, Rouse DJ, Peaceman AM, Sciscione A, Spong CY,
Varner MW, Malone FD, Iams JD, Mercer BM, Thorp JM Jr, Sorokin Y, Carpenter M, Lo
J, Ramin SM, Harper M; Eunice Kennedy Shriver National Institute of Child Health
and Human Development Maternal-Fetal Medicine Units Network. Relationship between
17-hydroxyprogesterone caproate concentrations and gestational age at delivery in
twin gestation. Am J Obstet Gynecol. 2012 Nov;207(5):396.e1-8. doi:
10.1016/j.ajog.2012.08.001. Epub 2012 Aug 6. PubMed PMID: 22959763; PubMed
Central PMCID: PMC3484214.

15: Corcoran TE, Venkataramanan R, Hoffman RM, George MP, Petrov A, Richards T,
Zhang S, Choi J, Gao YY, Oakum CD, Cook RO, Donahoe M. Systemic delivery of
atropine sulfate by the MicroDose Dry-Powder Inhaler. J Aerosol Med Pulm Drug
Deliv. 2013 Feb;26(1):46-55. doi: 10.1089/jamp.2011.0948. Epub 2012 Jun 12.
PubMed PMID: 22691110.

16: Huang Y, Lu J, Gao X, Li J, Zhao W, Sun M, Stolz DB, Venkataramanan R, Rohan
LC, Li S. PEG-derivatized embelin as a dual functional carrier for the delivery
of paclitaxel. Bioconjug Chem. 2012 Jul 18;23(7):1443-51. doi: 10.1021/bc3000468.
Epub 2012 Jun 20. PubMed PMID: 22681537; PubMed Central PMCID: PMC3399921.

17. Han K, Venkateswaran C, Venkataramanan R. Population pharmacokinetics of cyclosporine
AAPS Journal 2013 (In Press)

Pregnancy and Drug Metabolizing Enzymes and Transporters
NIH-NICHD
Raman Venkataramanan, PhD

T32 for Maternal fetal pharmacology
NICHD

Metabolism of 17-hydroxy progesterone caproate
OPRU
Raman Venkataramanan, PhD

Granisetron PK in pregnancy
Raman Venkataramanan, Ph.D.

Tamiflu Pk in Pregnancy
Raman Venkataramanan, Ph.D.

Remodlin for I/R injury of liver
Raman venkataramanan, Ph.D.

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