In the 38 years that Michael Mokotoff has taught at the School of Pharmacy, the scope and size of the school has changed as dramatically as the surrounding campus.

Hired in 1968 as a member of the Department of Medicinal Chemistry, Mokotoff specialized in peptide research as a follow-up to work he had started in a prior position with the National Institutes of Health. That research evolved into work on enzyme inhibitors for cancer chemotherapy, and later amino acid research.

Following a six-month sabbatical in 1978 at Israel's Weizmann Institute of Science, where he served as a visiting scientist, Mokotoff returned to teach biochemistry and medicinal chemistry. He later coordinated a course in endocrinology and taught both peptide and steroid chemistry.

During his tenure, Mokotoff branched out to tackle many topics as the need arose due to changes in the school's curriculum. He has taught selected lectures in areas ranging from oncology to psychiatry, cardiology, infectious diseases, drug metabolism, and immunology. For 26 years, he served as chair of the School of Pharmacy's academic performance committee, monitoring the progression and eventual graduation of students. In 1990, he was named by then-Governor Robert Casey to serve on the Pennsylvania Drug, Device, and Cosmetic Board, a post he held for eight years.

Mokotoff is a member of several national societies, notably the American Association for Cancer Research, the American Association of Pharmaceutical Scientists, the American and European Peptide Societies, and the American Association of Colleges of Pharmacy.

Mokotoff has been listed in Who's Who in America, Who's Who in Medicine and Healthcare, and Who's Who in Science and Engineering.