Office: 1004 Salk Hall

Phone: 412-624-8185

Fax: 412-383-7436

Email: gibbsr@pitt.edu

URL: www.pitt.edu/~gibbsr

Robert Gibbs is a Professor of Pharmaceutical Sciences at the University of Pittsburgh School of Pharmacy. He received a BS in Neuroscience, and a BA in Philosophy from the University of Rochester in 1981, and a Ph.D. in Biological Sciences from the University of California, Irvine in 1987.

His research focuses on the role of gonadal hormones in the regulation of cholinergic neurons, brain aging, and cognition. Recent interests focus on local estrogen production in the brain and how local production is influenced by injury and stress.

His research has been continuously funded by the National Institutes of Health or the National Science Foundation for over 20 years. He has served as an ad hoc reviewer for several NIH study sections, as a reviewer for over a dozen scientific journals, and has published over 90 scientific papers, book chapters, and reviews. He is co-editor of the book “Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies” published by Cambridge University Press. Memberships include the Society for Neuroscience, the Society for Behavioral Neuroendocrinology, and the American Association of Colleges of Pharmacy.

Effects of gonadal hormones on cholinergic neurons, brain aging, and cognition. Effects of injury and stress on local estrogen production in the brain, and the ability of local estrogen production to promote healing and reduce functional impairment.

Li, J., P. J. Oberly, S. Polloyac, R.B. Gibbs (2016) A microsomal based method to detect aromatase activity in different brain regions of the rat using ultra performance liquid chromatography-mass spectrometry. The Journal of steroid biochemistry and molecular biology. Journal of Steroid Biochemistry abnd Molecular Biology (In Press).

Gibbs, R.B., Nelson, D., Hammond, R.E. (2014) Role of GPR30 in mediating estradiol effects on acetylcholine release in the hippocampus, Hormones & Behavior, 66(2): 339-345. PMCID 4131743.

Ihunnah, C.A., T. Wada, B.J. Philips, S.K. Ravuri, R.B. Gibbs, L. Kirisci, J.P. Rubin, K.G. Marra, and W. Xie. (2014) Estrogen sulfotransferase/SULT1E1 promotes human adipogenesis. Molecular and cellular biology, 34(9): p. 1682-94. PMCID 3993609.

Ramaswamy, S., Dwarki, K., Ali, B., Gibbs, R.B., and Plant, T.M. (2012) The decline in pulsatile GnRH release, as reflected by circulating LH concentrations, during the infant-juvenile transition in the agonadal male rhesus monkey (Macaca mulatta) is associated with a reduction in kisspeptin content of KNDy neurons of the arcuate nucleus in the hypothalamus, Endocrinology, 154(5): p. 1845-53. PMCID 3628021.

Babalola, P.A., Fitz, N.F., Gibbs, R.B., Flaherty, P., Li, P.-K., Johnson, D.A. (2012) The Effects of The Steroid Sulfatase Inhibitor (p-o-sulfamoyl)–Tetradecanoyl Tyramine (DU-14) on Learning and Memory in Rats with Selective Lesion of Septal-Hippocampal Cholinergic Tract, Neurobiol. Learning and Memory, 98(3): 303-310. PMCID: 3491137

Hammond, R., Nelson, D., Kline, E., and Gibbs, R.B. (2012) Chronic treatment with a GPR30 antagonist impairs acquisition of a spatial learning task in young female rats, Hormones & Behavior, 62(4):367-74. doi: 10.1016/j.yhbeh.2012.07.004, PMCID: 3477261.

Cai, L., Gibbs, R.B., Johnson, D.A. (2012) Recognition of novel objects and their location in rats with selective cholinergic lesions of the medial septum. Neuroscience Letters, 506(2): 261-265. PMCID: 3462014.

Gibbs, R.B., Chipman, A.M., Hammond, R. and Nelson, D. (2011) Galanthamine Plus Estradiol Treatment Enhances Cognitive Performance in Aged Ovariectomized Rats, Horm. & Behav.60:607-616. doi:10.1016/j.yhbeh.2011.08.010. PMCID: 3210334.

Poloyac, S. M., Empey, K. M., Rohan, L. C., Skledar, J., Empey, P. E., Nolin, T. D., Bies, R. R., Gibbs, R. B., Folan, M., P.D., K., 2011. Core Competencies for Research Training in the Clinical Pharmaceutical Sciences. American Journal of Pharmaceutical Education. 72, 1-9. PMCID 3073101.

Gibbs, R.B., Chipman, A.M., and Nelson, D. (2011) Donepezil Plus Estradiol Treatment Enhances Learning and Delay-Dependent Memory Performance by Young Ovariectomized Rats with Partial Loss of Septal Cholinergic Neurons, Horm. & Behav., 59(4): 503-11. DOI S0018-506X(11)00026-2 [pii] 10.1016/j.yhbeh.2011.01.011; PMCID 3081392.

Hammond, R.*, and Gibbs, R.B. (2011) GPR30 is positioned to mediate estrogen effects on basal forebrain cholinergic neurons and cognitive performance, Brain Res, 1379:53-60, doi:10.1016/j.brainres.2010.11.098; PMCID 3046317.

Pokala, V.N., Witt-Enderby, P.A., Gibbs, R.B., and Johnson, D.A. (2010). Selective septohippocampal cholinergic lesioning in rat brain: Effects on muscarinic receptor function and secretase enzyme activity. Curr. Topics in Pharmacol. 14: 73-78.

Kline, A.E., McAloon, R.L., Henderson, K.A., Bansal, U.K., Ganti, B.M., Ahmed, R.H., Gibbs, R.B. and Sozda, C.N. (2010) Evaluation of a Combined Therapeutic Regimen of 8-OH-DPAT and Environmental Enrichment After Experimental Traumatic Brain Injury, J. Neurotrauma, 27:11, 2021-2032. DOI: 10.1089/neu.2010.1535; PMCID 2978058.

Hammond, R.*, Nelson, D., and Gibbs, R.B. (2010) GPR30 co-localizes with cholinergic neurons in the basal forebrain and enhances potassium-stimulated acetylcholine release in the hippocampus. Psychoneuroendocrinology, 36(2):182-192, DOI: 10.1016/j.psyceuen.2010.07.007. PMCID: 2994977

Gibbs, R.B. (2010) Does Short-Term Estrogen Therapy Produce Lasting Benefits In Brain? Endocrinology, 15(3): 843-845.

Gibbs, R.B. (2010) Estrogen therapy and cognition: A review of the cholinergic hypothesis, Endocrine Reviews 31(2): 224-253. PMCID: 2852210.

Ramaswamy, Gibbs, R.B., Plant, T.M. (2009) Studies of the localization and action of kisspeptin within the pituitary of the rhesus monkey (Macaca mulatta), Journal of Neuroendocrinology, 10: 795-804. PMCID: 2760459

Hammond, R., Mauk, R., Ninaci, D., Nelson, D., and Gibbs, R.B. (2009) Chronic treatment with estrogen receptor agonists restores acquisition of a spatial memory task in young ovariectomized rats. Horm. & Behav., 56: 309-314. PMCID: 2772993.

Gibbs, R.B., Mauk, R., Nelson, D., Johnson, D.A. (2009) Donepezil treatment restores the ability of estradiol to enhance cognitive performance in aged rats: Evidence for the cholinergic basis of the critical period hypothesis. Horm. & Behav., 56: 73-83. PMCID: 2737520

Fitz, N., Gibbs, R.B., and Johnson, D. (2008) Selective Lesions of Septal Cholinergic Neurons in Rats Impairs Acquisition of a Delayed Matching to Position T-maze Task by Delaying the Shift from a Response to a Place Strategy, Brain Res. Bull., 77: 356-360. PMCID: 2649660.

Ramaswamy, S., Guerriero, K.A., Gibbs, R.B., Plant, T.M. (2008) Structural interactions between kisspeptin and GnRH Neurons in the mediobasal hypothalamus of the male rhesus monkey (Macaca mulatta) as revealed by double immunofluorescence and confocal microscopy. Endocrinology, 149 (9): 4387-95. PMCID: 2553371.

Gibbs, R.B. and Johnson, D.A. (2008) Sex specific effects of gonadectomy and hormone treatment on acquisition of a 12-arm radial maze task by Sprague-Dawley rats. Endocrinology, 149(6): 3176-3183. PMCID: 2408814.

Impact of Estrogens and Menopause on Interacting Monoamine Neurotransmitters in the Brain
(R. Gibbs, J. Yao Co-PIs)
National Institutes of Health

Regulation of Aromatase in the Brain by Cholinergic Inputs and Cholinesterase Inhibitors
(R. Gibbs PI)
University of Pittsburgh Central Research Development Fund

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