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Procedures
Oral comprehensive exam proposals are to be submitted on NIH grant application form PHS 398 continuation pages (rev. 5/01) and prepared according to the directions in the application packet, with the exceptions noted below. Forms and instructions are available on the internet at:
http://grants.nih.gov/grants/funding/phs398/phs398.html
Do not exceed a total of ten pages for the following parts (a-d): Specific Aims, Background and Significance, Progress Report/Preliminary Studies, and Experimental Design and Methods. Tables and figures are included in the ten page limitation. Applications that exceed the page limitation or PHS requirements for type size and margins (Refer to PHS 398 application for details) will be returned for revision. The ten page limitation does not include parts e through i. (Human Subjects, Vertebrate Animals, or Literature Cited). Note that the written document cannot be substantively the same (i.e., the same hypothesis and specific aims) as a proposal presented for discussion in other classes or journal clubs.
(a) - Specific Aims – (1 page). List the broad, long-term objectives and what the specific research proposed in this application is intended to accomplish, e.g., to test a stated hypothesis, create a novel design, solve a specific problem, or develop new technology.
(b) - Background and Significance – (2-3 pages). Briefly sketch the background leading to the present application, critically evaluate existing knowledge, and specifically identify the gaps that the project is intended to fill. State concisely the importance and healthcare relevance of the research described in this application by relating the specific aims to the broad, long-term objectives.
(c) - Preliminary Studies/Progress Report – (2-3 pages). Use this section to provide an account of the students’/academic advisors’ preliminary studies pertinent to the application information that will also help to establish the feasibility of the proposed project.
(d) - Research Design and Methods – (4-5 pages). Describe the research design and the procedures to be used to accomplish the specific aims of the project. Include how the data will be collected, analyzed, and interpreted. Describe any new methodology and its advantage over existing methodologies. Discuss the potential difficulties and limitations of the proposed procedures and alternative approaches to achieve the aims. As part of this section, provide a tentative sequence or timetable for the project.
See http://grants.nih.gov/grants/funding/phs398/section_1.html#8_research for complete instructions regarding sections (e) and (f).
(e) – Human Subjects Research
(f) – Vertebrate Animals
(g) – Literature Cited. (No page limits). List all references. Each reference must include the title, names of all authors, book or journal, volume number, page numbers, and year of publication. The references should be limited to relevant and current literature. While there is not a page limitation, it is important to be concise and to select only those literature references pertinent to the proposed research.
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