Fifth year PhD candidate with strong interests in membrane transporters, 3D in vitro models, drug distribution, and pharmacometrics in mucosal tissues. My dissertation focuses on understanding biological factors affecting drug distribution in mucosal tissues using in vitro and ex vivo approaches.
Education & Training
BS, PharmD
Le, A., Graebing P., Wang., L., Zhang, J., Bies, R., & Rohan C. Determining critical physiological and drug specific parameters for enhancing a physiologically-based pharmacokinetics model for the female reproductive tract. Clinical Pharmacology and Therapeutics [POSTER ABSTRACT, Accepted, Published in March 2025] Le, A., Valicherla, G., Mohammed, R., Zhang, J., Chen, B., Chappel, C., Bies, R., & Rohan C. Expanding the gene expression profiling of drug transporters and drug metabolizing enzymes to include the upper female reproductive tract. Drug Metabolism and Disposition [Under Review] Collins, L., Le, A., Li, H., & Nicol, M. The cervicovaginal microenvironment and efficacy of tenofovir, emtricitabine, and lamivudine in ex vivo model for HIV prevention. PLoS One[Under Review] Le, A., Huang, K., & Cirrincione, L. Regulation of drug-metabolizing enzymes by sex-related hormones: clinical implications for transgender medicine. Trends in Pharmaceutical Sciences [In press] Tiwari, A., Kojiro T., Le, A., et al. Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of P53 to Promote Invasion and Metastasis. Gastroenterology [In press] Brewers, L., Emerson, C., Le, A., Nelson, J. A., Kashuba, A. D., & Nicol, M. R. (2018, October). Comparison of p24 and Spliced RNA to Quantify Viral Growth and Drug Response in Cervicovaginal Explants. AIDS RESEARCH AND HUMAN RETROVIRUSES (Vol. 34, pp. 356-356). October 10, 2018.
