Imam H Shaik

Assistant Professor

Imam Shaik is Assistant Professor of Pharmacy and Therapeutics at the University of Pittsburgh School of Pharmacy.
He received his B.Pharm and M.Pharm degrees from University college of Pharmaceutical Sciences of Kakatiya University, Warangal, and Ph.D. from Texas Tech University Health Sciences Center, Amarillo, TX. After a postdoctoral fellowship at the Texas Tech University Health Sciences Center and University of Pittsburgh, he served as a bioequivalence reviewer at the United States Food and Drug Administration. He joined the University of Pittsburgh as assistant professor in 2022.

He has been reviewer for several journals. He has presented at national and international meetings. He has published nearly 25 research articles.

Graduate Program Affiliation(s)
Clinical pharmaceutical scientist,Pharmaceutics
Center Affiliation(s)
Clinical Pharmaceutical Sciences Center
Practice Area/Expertise
Pharmacokinetics, Drug Metabolism, Clinical pharmacology
Recent Publications

1. Hansen-Estruch C, Bikhet MH, Shaik IH, Vasudevan V, Zhao W, Javed M, Collins DE, Ayares D, Judd E, Cooper DKC, Venkataramanan R. Assessment of glomerular filtration and tubular secretion in baboons with life-supporting pig kidney grafts. Xenotransplantation. 2023 Feb 23:e12795.
2. Almazroo OA, Shaik IH, Hughes CB, Humar A, Venkataramanan R. Treprostinil Supplementation Ameliorates Hepatic Ischemia Reperfusion Injury and Regulates Expression of Hepatic Drug Transporters: An Isolated Perfused Rat Liver (IPRL) Study. Pharm Res. 2022 Nov;39(11):2979-2990.
3. Liu Q, Huang H, Xu B, Li D, Liu M, Shaik IH, Wu X. Two Innovative Approaches to Optimize Vancomycin Dosing Using Estimated AUC after First Dose: Validation Using Data Generated from Population PK Model Coupled with Monte-Carlo Simulation and Comparison with the First-Order PK Equation Approach. Pharmaceutics. 2022 May 7;14(5):1004.
4. Nupur Chaphekar, Prerna Dodeja, Imam H. Shaik, Steve Caritis, and Raman Venkataramanan. Maternal-Fetal Pharmacology of Drugs: A Review of Current Status of the Application of Physiologically Based Pharmacokinetic Models. Frontiers in Pediatrics. 2021 Nov; 9: 733823.
5. Wu X, Zhang X, Xu R, Shaik IH, Venkataramanan R. Physiologically based pharmacokinetic modelling of treprostinil after intravenous injection and extended-release oral tablet administration in healthy volunteers: An extrapolation to other patient populations including patients with hepatic impairment. Br J Clin Pharmacol. 2021;1–13.
6. Almazroo OA, Miah MK, Pillai VC, Shaik IH, Xu R, Dharmayan S, Johnson HJ, Ganesh S, Planinsic RM, Demetris AJ, Al-Khafaji A, Lopez R, Molinari M, Tevar AD, Hughes C, Humar A, Venkataramanan R. An evaluation of the safety and preliminary efficacy of peri- and post- operative treprostinil in preventing ischemia and reperfusion injury in adult orthotopic liver transplant recipients. Clin Transplant. 2021 Mar 25:e14298.
7. Coons JC, Crisamore K, Adams S, Modany A, Simon MA, Zhao W, Shaik IH, Venkataramanan R, Empey PE. A pilot study of oral treprostinil pharmacogenomics and treatment persistence in patients with pulmonary arterial hypertension. Ther Adv Respir Dis. 2021 Jan-Dec;15: 17534666211013688.
8. Imam H. Shaik, Jaime R Bastian, Yang Zhao, Steve Caritis, and Raman Venkataramanan. Route of Administration and Formulation Dependent Pharmacokinetics of 17-Hydroxyprogesterone Caproate in Rats. Xenobiotica 2016; 46(2): 169-74.
9. Omar M Young, Imam H Shaik, Roxanna Twedt, Anna Binstock, Andrew D Althouse, Raman Venkataramanan, Hyagriv N Simhan, Harold C Wiesenfeld, Steve N Caritis. Pharmacokinetics of cefazolin prophylaxis in obese gravidae at time of cesarean delivery. Am. J. Obstetrics and Gynecology. 2015 Oct; 213(4): 541.e1-7.
10. Miah MK, Shaik IH, Bickel U, Mehvar R. Effects of Pringle maneuver and partial hepatectomy on the pharmacokinetics and blood brain barrier permeability of sodium fluorescein in rats. Brain. Res. 2015 Aug 27; 1618:249-60.
11. Miah MK, Shaik IH, Bickel U, Mehvar R. Effects of hepatic ischemia-reperfusion injury on the P-glycoprotein activity at the liver canalicular membrane and blood-brain barrier determined by in vivo administration of rhodamine 123 in rats. Pharm Res. 2014 Apr;31(4):861-73.
12. Shaik IH, Miah MK, Bickel U, Mehvar R. Effects of short-term portacaval anastomosis on the peripheral and brain disposition of the blood-brain barrier permeability marker sodium fluorescein in rats. Brain Res. 2013 Sep 19; 1531: 84-93.
13. Gupta V, Gupta N, Shaik IH, Mehvar R, Nozik-Grayck E, McMurtry IF, Oka M, Komatsu M, Ahsan F. Inhaled PLGA particles of prostaglandin E1 ameliorate symptoms and progression of pulmonary hypertension at a reduced dosing frequency. Mol Pharm. 2013 May 6; 10(5):1655-67.
14. Gupta V, Gupta N, Shaik IH, Mehvar R, McMurtry IF, Oka M, Nozik-Grayck E, Komatsu M, Ahsan F. Liposomal fasudil, a rho-kinase inhibitor, for prolonged pulmonary preferential vasodilation in pulmonary arterial hypertension. J Control Release. 2013 Apr 28;167(2):189-99.
15. Shaik IH, Agarwal HK, Parang K, and Mehvar R. Local Immunosuppressive Effects of Systemically Administered Novel Dextran-Methylprednisolone Prodrugs with Peptide Linkers in Rat Livers. J Pharm Sci. 2012 Oct;101(10):4003-12.
16. Parasrampuria R, Shaik IH, Mehvar R. Effects of in vivo hepatic ischemia-reperfusion injury on the hepatobiliary disposition of rhodamine 123 and its metabolites in isolated perfused rat livers. J Pharm Pharm. Sci. 2012 Jan; 15(2):318-28.
17. Shaik IH and Mehvar R. Effects of normothermic hepatic ischemia-reperfusion injury on the in vivo, isolated perfused liver, and microsomal disposition of chlorzoxazone, a cytochrome P450 2E1 probe, in rats. J Pharm Sci. 2011 Dec; 100(12):5281-8292.
18. Shaik IH and Mehvar R. Cytochrome P450 induction by phenobarbital exacerbates warm hepatic ischemia-reperfusion injury in rat livers. Free Rad Res. 2010 Apr; 44(4):441-53.
19. Pillai VC, Yesudas R, Shaik IH, Thekkumkara TJ, Bickel U and Mehvar R. Delivery of NADPH-cytochrome P450 reductase antisense oligos using avidin-biotin approach. Bioconjugate Chemistry, 2010 Feb 17; 21(2):203-7.
20. Shaik IH and Mehvar R. Effects of cytochrome P450 inhibition by cimetidine on the warm hepatic ischemia-reperfusion injury in rats. J Surg Res. 2010 Apr; 159(2):680-8.
21. Shaik IH, George JM, Thekkumkara TJ, and Mehvar R. Protective effects of diallyl sulfide, a garlic constituent, on the warm hepatic ischemia-reperfusion injury in a rat model. Pharm Res. 2008 Oct; 25(10): 2231-42.
22. Vad NM, Shaik IH, Mehvar R, Moridani MY. Metabolic bioactivation and toxicity of ethyl 4-hydroxybenzoate in human SK-MEL-28 melanoma cells. J Pharm Sci. 2008 May; 97(5): 1934-1945.
23. Shaik IH, Mehvar R. Rapid determination of reduced and oxidized glutathione levels using a new thiol-masking reagent and the enzymatic recycling method: application to the rat liver and bile samples. Anal Bioanal Chem. 2006 May; 385(1): 105-13.
24. Chimalakonda AP, Montgomery DL, Weidanz JA, Shaik IH, Nguyen JH, Lemasters JJ, Kobayashi E, Mehvar R. Attenuation of acute rejection in a rat liver transplantation model by a liver-targeted dextran prodrug of methylprednisolone. Transplantation. 2006 Mar 15; 81(5):678-85.